What are the Side Effects of Aromatase Inhibitors

What are the Side Effects of Aromatase Inhibitors

If you have your menopause while on tamoxifen, your doctor might suggest you switch to an aromatase inhibitor such as letrozole. Your doctor mightrecommend that you take it for another 5 years after this if there is a high risk of your cancer coming back. They will weigh up the benefit of taking the drug for longer with other factors, such as any side effects you have and whether you want to have children. Your doctor might change you to a different type of hormone treatment if your cancer starts growing again. For example, you might be able to have just the tumour removed (a lumpectomy) instead of the whole breast (mastectomy). It is also a possible treatment for breast cancer that has spread to other parts of the body.

This would help make sure patients have access to affordable, appropriate treatment. As a result, people often find themselves facing high out-of-pocket costs when filling prescriptions for oral cancer drugs. Susan G. Komen® created the Komen Financial Assistance Program to help those struggling with the costs of breast cancer treatment by providing financial assistance to eligible individuals. Learn more about the importance of following your breast cancer treatment plan.

  • There is growing evidence that aromatase may benefit more than just postmenopausal women.
  • Your doctor might change you to a different type of hormone treatment if your cancer starts growing again.
  • The most common way to have hormone therapy for breast cancer is after surgery.
  • Women usually begin the drug after undergoing surgery to remove a breast tumor.
  • Aromatase is the enzyme responsible for the conversion of testosterone to estrone (E1) and androstenedione to estradiol (E2).

Joint pain (arthralgia) and muscle pain (myalgia) are common side effects of aromatase inhibitors [ ]. The pain may be in the hands and wrists, feet and ankles, knees, back or other parts of the body. Joint and muscle pain are most common after you’ve been sleeping or inactive.

Side effects of aromatase inhibitors versus side effects of tamoxifen

Aromatase inhibitors are a class of medicines that work by blocking the enzyme aromatase, the enzyme that converts androgens into estrogen. Aromatase inhibitors are used in the treatment of breast cancer to reduce levels of circulating estrogen. This means that less estrogen is available to stimulate the growth of estrogen receptor (ER) positive breast cancer cells, slowing or inhibiting the progression of these cancers.

Approximately 90% of breast cancers in men are ER positive and approximately 80% are PR positive (3). If the hot flashes bother you, talk with your health care provider about ways to treat them. Hot flashes and night sweats are common in women who take aromatase inhibitors [102].


Patients react differently to https://summitadyawinsa.co.id/2024/02/05/experts-recommend-optimal-andriol-dosage-for/, but few experience side effects severe enough to interfere with daily life. Aromatase inhibitors don’t stop the ovaries from making estrogen. If your ovaries are still functioning, aromatase inhibitors will have no effect. Talk with your health care provider about how long you should take an aromatase inhibitor.

Aromatase inhibitors are the most effective medications today for treating or preventing the recurrence of estrogen-fueled breast cancers in post-menopausal women. Aromatase inhibitors are among the most effective medications today for treating or preventing the recurrence of estrogen-fueled breast cancers in post-menopausal women. Drugs called aromatase inhibitors can stop the body from making estrogen and deny cancer cells the fuel they need to grow. Aromatase inhibitors are unable to prevent the ovaries from making estrogen, which means that they are only used to treat breast cancer in postmenopausal women. The American Society for Clinical Oncology (ASCO), the National Comprehensive Cancer Network (NCCN) and the U.S.

The side effects of hormone therapy depend largely on the specific drug or the type of treatment (7). The benefits and harms of taking hormone therapy should be carefully weighed for each person. Anastrozole, a selective aromatase inhibitor, is available as a 1 mg tablet, which is to be taken orally once a day, with or without food. No dose adjustment is necessary for patients with renal or liver impairment or elderly patients. Aromatase inhibitors are a type of hormone therapy drug used to treat breast cancer in women who have gone through a natural menopause (when periods stop).

In addition, it may be used in premenopausal women who have had ovarian ablation. Estrogen and progesterone also promote the growth of some breast cancers, which are called hormone-sensitive (or hormone-dependent) breast cancers. Hormone-sensitive breast cancer cells contain proteins called hormone receptors (estrogen receptors, or ERs, and progesterone receptors, or PRs) that become activated when hormones bind to them. The activated receptors cause changes in the expression of specific genes, which can stimulate cell growth. For men with breast cancer, the 2020 American Society of Clinical Oncology Guidelines recommend tamoxifen be used instead of an aromatase inhibitor to reduce the risk of breast cancer recurrence. An aromatase inhibitor (in combination with ovarian suppression therapy) may be considered, however, for men who are unable to take tamoxifen for some reason.

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